The struggle of people with various viral and infectious diseases is similar to a game of chess. For every action of mankind, viruses and bacteria "come up" with resistance. But in the case of the fight against HIV, this game is more like a giveaway, where people act far from being an attacking party. But people are not used to giving up and continuing the battle. Moreover, it is possible to achieve significant success today. For example, researchers from the University of California and Stanford created a synthetic molecule capable of reactivating the dormant immunodeficiency virus and destroying the cells infected by it.
A group of scientists led by Matthew Marsden and Jerome Zach for a long time studied ways to destroy infected cells by stimulating the production of particles that cause a response of the immune system, which also destroys the infected cell. As it turned out, such a "stimulant" can be a molecule of briostatin 1, but it is extremely expensive and difficult to obtain, because it is organic and "extraction" comes from marine invertebrates such as bugula neritina.
Thus, scientists decided to create an artificial molecule that would be analogous to briostatin 1 and surpassed it in a number of parameters. The resulting molecule was named SUW133. It, like the natural analogue, is also capable of influencing HIV. In a series of experiments in mice, it was found that SUW133 stimulates protein production in infected mice and destroys 25% of them in the first 24 hours.
According to the authors of the study, it has very good prospects, because as a result of antiretroviral therapy, the spread of the disease can be stopped, and the virus itself is able to "hide" in the carrier cells for a long time. Thus, the additional destruction of the virus that has passed into the latent phase is an extremely important part of the treatment.
The article is based on materials .
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