With age, the cells of our body wear out. Worn cells are not always removed from the body in a timely manner and as a result of this, they begin to “infect” the surrounding tissues and other cells. This process is called cell aging, which ultimately leads not only to the aging of the body, but can cause various diseases, including cancer. Scientists from the Mayo Clinic (USA, one of the largest clinics in the world) have shown in experiments on laboratory mice that removing these worn cells from the body can improve their health and life expectancy up to 35 percent and without any side effects.
Despite the fact that normally worn cells are eventually excreted from the body due to the immune system, over time (with age) the immune system becomes less and less effective and ceases to cope with this task. This leads to the spread of worn cells and as a result - the aging of the body. Even though these cells can no longer divide, they can still damage the surrounding tissue and cells with special compounds that they secrete. This ultimately can lead to the development of age-related diseases.
To assist the immune system in cleansing the body of mice from unwanted cells, scientists from the Mayo Clinic used the drug they had created, which was experimentally named AP20187. The introduction of the drug really helped get rid of worn cells. At the same time, scientists noted that the places and foci of tumor formation, as well as the deterioration of the internal organs of rodents, have decreased dramatically. Moreover, the life cycle of such mice in different cases increased from 17 to 35 percent, and in the adipose and muscular tissues, as well as the kidneys, inflammatory processes sharply decreased.
“The worn-out cells that accumulate inside the body with age cause serious damage to your organs and tissues, shortening your life and health,” says Jan van Derser, one of the leading authors of the study.
“And since it is possible to remove these cells from the body without any side effects, our genetic model that we used proved that the use of special drugs and drugs that can worn out cells would be a very useful weapon for therapists against age-related diseases.”
The main author of this study, Darren Baker, adds that the experimental drug they received is very effective and can lead to a significant improvement in health, as it is able to remove from the body from 60 to 70 percent of worn cells.
"The drug is able to effectively and quickly remove a sufficient number of worn cells to affect the overall health and longevity of the body," - said the scientist.
The article is based on materials .
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